SAMe by Bioclinic Naturals SAMe by Bioclinic Naturals

$ 29.60
Servings Per Container: 30 

Take on an empty stomach:

For mood balance: 1–4 tablets 2 times per day or as directed by a health care professional.

For joint support: 1–3 tablets 2 times per day or as directed by a health care professional. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.


Serving Size: 1 Tablet 

Amount Per Serving 
SAMe S-Adenosyl-L-Methionine
 ... 200mg 
(from 400 mg SAMe Tosylate Disulfate)

Other ingredients: Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides (coconut), yellow iron oxide), glyceryl behenate, magnesium stearate (vegetable grade), silica, sodium starch glycolate.

Contains no artificial preservatives or sweeteners; no dairy, gluten, soy, wheat or yeast.

S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways. Well-recognized as a unique methyl donor for numerous biological reactions, including DNA methylation, it also links methylation to polyamine synthesis (necessary for cell survival and growth), and trans sulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis. Its unique positioning within these intersecting pathways explain its role as a regulator of redox status, cellular metabolism, proliferation and apoptosis.

Clinically it has proven beneficial for a number of conditions, most notably osteoarthritis, neurodegenerative disease, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard antidepressants, but also for selective serotonin reuptake inhibitor (SSRI) nonresponders. SAMe has also shown efficacy for osteoarthritis comparable to NSAIDs, including celecoxib. Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical analgesics. Research also suggests benefit for neurodegenerative disease, and potentially for improving endothelial function.

Benefits
•Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity 
•Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form 
•Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption 
•200 mg SAMe per tablet, allows for flexible dose titration 
•Sourced from the highest quality Italian Isoactive® SAMe available on the market 
•Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations

Servings Per Container: 30 

Take on an empty stomach:

For mood balance: 1–4 tablets 2 times per day or as directed by a health care professional.

For joint support: 1–3 tablets 2 times per day or as directed by a health care professional. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.


Serving Size: 1 Tablet 

Amount Per Serving 
SAMe S-Adenosyl-L-Methionine
 ... 200mg 
(from 400 mg SAMe Tosylate Disulfate)

Other ingredients: Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides (coconut), yellow iron oxide), glyceryl behenate, magnesium stearate (vegetable grade), silica, sodium starch glycolate.

Contains no artificial preservatives or sweeteners; no dairy, gluten, soy, wheat or yeast.

S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways. Well-recognized as a unique methyl donor for numerous biological reactions, including DNA methylation, it also links methylation to polyamine synthesis (necessary for cell survival and growth), and trans sulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis. Its unique positioning within these intersecting pathways explain its role as a regulator of redox status, cellular metabolism, proliferation and apoptosis.

Clinically it has proven beneficial for a number of conditions, most notably osteoarthritis, neurodegenerative disease, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard antidepressants, but also for selective serotonin reuptake inhibitor (SSRI) nonresponders. SAMe has also shown efficacy for osteoarthritis comparable to NSAIDs, including celecoxib. Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical analgesics. Research also suggests benefit for neurodegenerative disease, and potentially for improving endothelial function.

Benefits
•Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity 
•Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form 
•Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption 
•200 mg SAMe per tablet, allows for flexible dose titration 
•Sourced from the highest quality Italian Isoactive® SAMe available on the market 
•Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations

Availability: 10 In Stock
Sku: 2360
Servings Per Container: 30 

Take on an empty stomach:

For mood balance: 1–4 tablets 2 times per day or as directed by a health care professional.

For joint support: 1–3 tablets 2 times per day or as directed by a health care professional. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.


Serving Size: 1 Tablet 

Amount Per Serving 
SAMe S-Adenosyl-L-Methionine
 ... 200mg 
(from 400 mg SAMe Tosylate Disulfate)

Other ingredients: Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides (coconut), yellow iron oxide), glyceryl behenate, magnesium stearate (vegetable grade), silica, sodium starch glycolate.

Contains no artificial preservatives or sweeteners; no dairy, gluten, soy, wheat or yeast.

S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways. Well-recognized as a unique methyl donor for numerous biological reactions, including DNA methylation, it also links methylation to polyamine synthesis (necessary for cell survival and growth), and trans sulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis. Its unique positioning within these intersecting pathways explain its role as a regulator of redox status, cellular metabolism, proliferation and apoptosis.

Clinically it has proven beneficial for a number of conditions, most notably osteoarthritis, neurodegenerative disease, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard antidepressants, but also for selective serotonin reuptake inhibitor (SSRI) nonresponders. SAMe has also shown efficacy for osteoarthritis comparable to NSAIDs, including celecoxib. Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical analgesics. Research also suggests benefit for neurodegenerative disease, and potentially for improving endothelial function.

Benefits
•Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity 
•Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form 
•Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption 
•200 mg SAMe per tablet, allows for flexible dose titration 
•Sourced from the highest quality Italian Isoactive® SAMe available on the market 
•Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations

Servings Per Container: 30 

Take on an empty stomach:

For mood balance: 1–4 tablets 2 times per day or as directed by a health care professional.

For joint support: 1–3 tablets 2 times per day or as directed by a health care professional. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.


Serving Size: 1 Tablet 

Amount Per Serving 
SAMe S-Adenosyl-L-Methionine
 ... 200mg 
(from 400 mg SAMe Tosylate Disulfate)

Other ingredients: Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides (coconut), yellow iron oxide), glyceryl behenate, magnesium stearate (vegetable grade), silica, sodium starch glycolate.

Contains no artificial preservatives or sweeteners; no dairy, gluten, soy, wheat or yeast.

S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways. Well-recognized as a unique methyl donor for numerous biological reactions, including DNA methylation, it also links methylation to polyamine synthesis (necessary for cell survival and growth), and trans sulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis. Its unique positioning within these intersecting pathways explain its role as a regulator of redox status, cellular metabolism, proliferation and apoptosis.

Clinically it has proven beneficial for a number of conditions, most notably osteoarthritis, neurodegenerative disease, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard antidepressants, but also for selective serotonin reuptake inhibitor (SSRI) nonresponders. SAMe has also shown efficacy for osteoarthritis comparable to NSAIDs, including celecoxib. Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical analgesics. Research also suggests benefit for neurodegenerative disease, and potentially for improving endothelial function.

Benefits
•Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity 
•Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form 
•Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption 
•200 mg SAMe per tablet, allows for flexible dose titration 
•Sourced from the highest quality Italian Isoactive® SAMe available on the market 
•Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations

Shipping & Returns

All In-stock items usually ship within 1-2 business days. Any orders placed on items on backorders are shipped in 3-5 business days. Hassle-Free Returns In order to return merchandise, you must obtain an RMA number from parib1950@gmail.com. You may return any unopened merchandise in its original condition, including original packaging and packing slip within 30 days of receipt and you will receive a full refund less shipping and any gift wrapping charges. We charge a 20% restocking fee for any merchandise not returned in its original condition and packaging. Any shipping cost you incur to return the product to us will not be refunded. Shipping cost is non-refundable for undelivered, unclaimed or returned packages, unless we made an error..

Shipping & Returns

All In-stock items usually ship within 1-2 business days. Any orders placed on items on backorders are shipped in 3-5 business days. Hassle-Free Returns In order to return merchandise, you must obtain an RMA number from parib1950@gmail.com. You may return any unopened merchandise in its original condition, including original packaging and packing slip within 30 days of receipt and you will receive a full refund less shipping and any gift wrapping charges. We charge a 20% restocking fee for any merchandise not returned in its original condition and packaging. Any shipping cost you incur to return the product to us will not be refunded. Shipping cost is non-refundable for undelivered, unclaimed or returned packages, unless we made an error..
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